Lipid-Based Nanoparticles for Delivery of Vaccine Adjuvants and Antigens: Toward Multicomponent Vaccines
نویسندگان
چکیده
Despite the many advances that have occurred in field of vaccine adjuvants, there are still unmet needs may enable development vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) cancer vaccines. Liposomes already been shown to be highly effective as adjuvant/delivery systems due their versatility likely will find further uses this space. The broad potential lipid-based delivery is highlighted by recent approval COVID-19 comprising lipid nanoparticles with encapsulated mRNA. This review provides an overview different approaches can evaluated design protein, carbohydrate, nucleic acid-based antigens how these strategies might combined develop multicomponent
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2021
ISSN: ['1543-8384', '1543-8392']
DOI: https://doi.org/10.1021/acs.molpharmaceut.1c00447